Our very senior Great Dane was struggling with dementia or Sundowning. She takes medication for her hip pain, but at nights she was restless, walking around the house confused, and just agitated. After a night of zero sleep for both of us, I order 3 boxes to try. We are giving her 2 -3 at night with her bedtime pills and it has made a huge difference. She is now sleeping about 90% of the night without getting up and wondering around. Just wish they were softer because of her teeth.